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Regulatory press release

CRNA: Circio invites to R&D and corporate update webcast on 28 May 2025

Circio Holding
· CTO Dr. Thomas B Hansen will present a summary of recent in vivo results
validating circVec performance in novel AAV and DNA formats for gene and cell
therapy
· CEO Dr. Erik D Wiklund will provide a corporate and business development
update, incl.  information related to the upcoming annual general meeting

Oslo, Norway 22 May 2025 - Circio Holding ASA (OSE: CRNA), a biotechnology
company developing powerful circular RNA technology for next generation nucleic
acid medicine, invites to a live webcast at 10:00am CEST on Wednesday 28 May
2025.

In the webcast, CTO Dr. Thomas B Hansen will present CircioŽs latest circVec
platform in vivo results. Recent findings include validation of the circVec
platform using novel AAV and DNA vector formats, and demonstrate enhanced and
distinct tissue expression profiles vs. equivalent conventional mRNA-based
vectors. The results highlight potential applications for circVec in tissue
targeted gene therapy and in vivo cell therapy
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