contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
      researchContentUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
            nav
            navPerShare
            opexOfNav
            quarterlySharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
            nav
            navPerShare
            opexOfNav
            quarterlySharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

Analyst

Antti Siltanen

Faron is a global, clinical-stage biopharmaceutical company, focused on tackling cancers via novel immunotherapies. Its mission is to bring the promise of immunotherapy to a broader population by uncovering novel ways to control and harness the power of the immune system. The Company's lead asset is bexmarilimab, a novel anti-Clever-1 humanized antibody, with the potential to remove immunosuppression of cancers through reprogramming myeloid cell function. Bexmarilimab is being investigated in Phase I/II clinical trials as a potential therapy for patients with hematological cancers in combination with other standard treatments.

More Chinese studies:                  SpringerLink              Gastric cancer cells-derived exosomal miR-151a-5p induces an...    Journal of Experimental & Clinical Cancer Research - The incidence and mortality of gastric cancer (GC) are still in the forefront worldwide. Up to now, the population benefiting from...                             Abstract translation:  The incidence and mortality of gastric cancer (GC) remain at the forefront globally. To date, the population benefiting from immunotherapy is still very limited. Tumor-associated macrophages (TAMs) play an important role in immune response and immune microenvironment remodeling. The aim of this study was to investigate altered TAM subgroups in the gastric microenvironment and to elucidate the intrinsic molecular mechanism.

I completely disagree. Competition is only good, and when the competition comes from a completely different direction, it’s harder to assess the opponent.

I think Faron should try to stir up interest (FOMO - fear of missing out) from Western BP by hinting at negotiations with the Chinese. After all, they also have financial resources. From the numerous research results that are now coming to light, one inevitably gets the feeling that Phase III is falling short of reality.

The Chinese have significantly increased research, especially in medicine, and as is well known, they have ample resources and efficiency. Hopefully, they will notice the potential of Bexmarilimab, and it must also be noted that in addition to copying, they also seek shortcuts by acquiring companies on the verge of breakthroughs or those with existing patents. There are plenty of examples of this in the industrial sector.

It doesn’t directly go into Bex’s (BEX) domain, but clearly supports the mechanism Bex aims for: Macrophages can keep T-cells away and reduce the effectiveness of immunotherapy. Almost identical studies regarding the mechanism have recently been seen in several cancers (colon, ovarian, liver, lung, breast, and bladder). So, this is primarily a confirmation of a hypothesis, not a single drug. Bex comes into play because it targets the regulation of Clever-1 macrophages, which is one of the upstream mechanisms. This paper shows the problem, Bex tries to solve it. And yes, many other myeloid targets are being developed globally, e.g., CD47, TREM2, CSF1R. Many of them have just faced clinical challenges.

The Chinese have a vast amount of data to study. Hats off to them. Am I to understand that the results will directly benefit BEX? Don’t the Chinese have their own “Bex”?

Journal for ImmunoTherapy of Cancer              Targeting SPP1+TAMs associated with liver metastasis reverses...    Background Tumor-associated macrophages (TAMs) are critically involved in colorectal cancer (CRC) progression, yet their spatial and metabolic heterogeneity across primary and metastatic microenvironments remains poorly defined, limiting therapeutic...                             Targeting SPP1+TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer A new JITC paper on colorectal cancer hits the nail on the head: SPP1+ macrophages prevent CD8 T-cell entry into the tumor and drive liver metastases. When this macrophage environment is dismantled (regorafenib + PD-1), T-cells return and immunotherapy starts to work. This again supports the idea that the problem is not in T-cells but in the macrophage environment. SPP1+ TAM is a prominent endpoint, while Clever-1 (Stabilin-1) is an upstream regulator of macrophages. There is no direct evidence that they are the same pathway, but clearly the same immunosuppressive network… and Bex hits this more directly.

Faron Pharmaceuticals

Faron Pharmaceuticals is a clinical stage biopharmaceutical company whose three drug candidates relate to the modulation of immune system or inflammatory response. Faron is a very high-risk ...

<p>Faron Pharmaceuticals is a clinical stage biopharmaceutical company whose three drug candidates relate to the modulation of immune system or inflammatory response. Faron is a very high-risk investment as drug development requires frontloaded investments in research, while the success of commercialization is very uncertain. If the drug candidates enter the market, the invested capital can be multiplied. However, failure of drug development is frequent and, in that case, the invested capital may be partially or totally lost. We believe the share provides sufficient expected return to counterbalance the high risk. The share is suitable for a long-term investor that tolerates high risk as part of a well-diversified portfolio. A person investing in Faron must also be prepared for share issues.</p> 

	2021	22e	23e
Revenue	0.0	0.0	0.0
growth-%
EBIT (adj.)	-21.1	-22.0	-0.8
EBIT-% (adj.)	-527,700.0 %	-550,000.0 %	-19,500.0 %
EPS (adj.)	-0.38	-0.39	-0.02
Dividend	0.00	0.00	0.00
Dividend %
P/E (adj.)	neg.	neg.	neg.
EV/EBITDA	neg.	neg.	neg.

Risky investment with huge potential

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Key Estimate Figures08.08.2022

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