contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


synact-pharma-completes-clinical-pharmacokinetic-test-of-ap1189-tablet

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

SynAct Pharma operates in the pharmaceutical industry and focuses on the development of innovative treatments for inflammatory diseases. The company researches new therapies that can reduce inflammation and improve patient outcomes. The business is global with a primary presence in Europe and North America. SynAct Pharma was founded in 2012 and is headquartered in Lund, Sweden.

SynAct Pharma

The study was setup with three parts. In part 1 of the study, AP1189 formulated as fast release tablets, was tested in 12 healthy volunteers in cross over design with the previously used AP1189...

The study was setup with three parts. In part 1 of the study, AP1189 formulated as fast release tablets, was tested in 12 healthy volunteers in cross over design with the previously used AP1189 suspension as control. The pharmacokinetic profile of the tablets was similar to that of the suspension with fast absorption and maximal plasma concentration reached within 2 to 3 hours following dosing. The exposure evaluated through area under the curve (AUC) was numerically higher on the tablet whereas the maximum exposure was almost identical between the two formulations. Three out of 12 subjects developed nauseas following dosing with the suspension, whereas no incidents of nausea following dosing with the tablets were reported.In the second part of the study, the tablets were tested in a cross over design in 12 volunteers. On one occasion the tablet was dosed in the fasted state, at the other occasion the tablet was dosed following intake of a high fat diet. Dosing following intake of a high fat diet meal delayed the absorption of the compound meaning that time to maximal exposure was delayed by approximately 2 hours and the maximum concentration in plasma was lower (mean reduction by 33% compared to fasting state), whereas the overall exposure evaluated by AUC was only affected to minor degrees. These results are in line with what would be expected from the compound's physical and chemical characteristics and will not change the current dosing regimen.In the third part of the study, dose linearity in the range of 50 to 300 mg was tested in 12 healthy volunteers. The data showed an almost ideal dose linearity with r[2] =0.99."The data generated on our new tablet formulation is very encouraging. The major purpose of developing the fast release tablet was to increase patient convenience with the hope that the exposure profile could be comparable to the profile after dosing with the suspension. The tablet exposure profile seems to be as attractive, if not better, than the suspension's profile. That the nausea present in a subset of subjects treated with the suspension seems to be absent following dosing with the tablet is a major achievement. We look very much forward to continue the development of our AP1189 compound using the new tablet", says Thomas Jonassen, CSO.&nbsp;&nbsp;The information was submitted, through the agency of the contact person below, for publication&nbsp;at 08:00 CEST on May 4,&nbsp;2022.