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Research

Herantis H1'25: New results expected in the coming weeks

By Antti SiltanenAnalyst
Herantis Pharma
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Translation: Original published in Finnish on 8/21/2025 at 7:57 pm EEST.

Herantis' early part of the year proceeded as expected and on schedule. The ongoing clinical trial is in its final stages, and key results are expected by mid-October. Based on the well-progressed trial, we are moderately raising our estimate for the success of Phase I. We reiterate our Accumulate recommendation and raise our target price to EUR 2.1 (was EUR 1.9) based on DCF model.

No big surprises in the figures

In terms of figures, there were no surprises in the earnings release, and operating expenses were in line with our expectations. However, other operating income was lower than our estimate and the comparison period. As a result, the EBIT (-2.96 MEUR) was slightly below our estimate (-2.14 MEUR), which is of minor practical significance. Herantis had increased its staff, with which the company is particularly strengthening investor communications and aiming for more international visibility.

Research in Parkinson’s disease has progressed according to plans and on schedule

Herantis is conducting a clinical trial whose main objective is to evaluate the safety and tolerability of subcutaneously administered HER-096 in both healthy volunteers and patients with Parkinson's disease. The company recently announced that the final patient visit for the study had been completed on schedule. Initial results are expected by mid-October and a full analysis of the results at the end of the year. Results have been promising so far. Based on the data so far, it appears that the company would have no obstacles to moving to Phase II in terms of results. However, more robust conclusions can only be drawn once the full results of Phase I are available.

Current funding sufficient to prepare for Phase II

Cash reserves at the end of H1’25 were 4.56 MEUR, and we estimate them to be sufficient until late H1’26. The implementation of Phase II requires additional funding, which the company is seeking through a partnering agreement, although Herantis has other options available. Securing funding, alongside future research results, is crucial for the development of the investment story over the next year.

We increase the probability of success

Our earnings estimates decline moderately in the coming years based on our assessment of increasing operating costs and a lower level of other operating income. We raise the probability of success for the Phase I study in our model by five percentage points to 75%, based on the trial’s progress and promising results. The increased probability increases the likelihood of future cash flows materializing and increases the share's value in the DCF model.

Risk-adjusted DCF modeling suggests that the stock is attractively priced considering the risks

Our DCF model gives the share a value of EUR 2.1 and suggests attractive pricing. Our risk-adjusted forecasts consider the significant risk of failure in drug development, which we estimate is almost 90%. The value of the share can be realized not only through licensing-based cash flows, but also through a partnership agreement or a takeover bid. New trial results available in October may lower the share’s risk profile if the results are favorable. The investment profile is characterized by a significant return potential with a lower probability and a possibility of loss of capital with a higher probability.

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Herantis Pharma Plc is a clinical-stage biotechnology company developing disease modifying therapies for Parkinson’s disease. Herantis’ lead product HER-096 is a small synthetic chemical peptidomimetic molecule developed based on the active site of the CDNF protein. HER-096 combines the mechanism of action of CDNF with subcutaneous administration. The Phase 1a clinical trial demonstrated a good safety and tolerability profile as well as blood-brain barrier penetration of subcutaneously administered HER-096. The shares of Herantis are listed on the Nasdaq First North Growth Market Finland.

Read more on company page

Key Estimate Figures22.08.2025

202425e26e
Revenue0.00.00.0
growth-%150.0 %
EBIT (adj.)-5.0-5.5-5.9
EBIT-% (adj.)-50,270.0 %-55,119.0 %-59,321.2 %
EPS (adj.)-0.25-0.25-0.25
Dividend0.000.000.00
Dividend %
P/E (adj.)neg.neg.neg.
EV/EBITDAneg.neg.neg.

Forum discussions

100 percent so, gratefull feelings amomg many PD patients and Michael J Fox foundation💘
1 hour ago
by Oxymoron 007
0
It was nice to read the excellent news. I wouldn’t be surprised if there were a takeover bid for Herantis in the coming months, as it is a “...
7 hours ago
0
Alright, the long-awaited news is finally here. The biggest benefit of this data is likely in the design of Phase II endpoints. By utilizing...
9 hours ago
by jerej
7
I’m keeping my fingers crossed but I’m not holding my breath… let’s hope for the best for both the company and PD patients, if maybe this HER...
10 hours ago
by TomPettynyt
2
This will become a competition between Big Pharma companies over who gets to be part of this. There are plenty of interested parties. And I ...
10 hours ago
by j.sälli
1
Well then, an interesting day coming up on the stock market tomorrow for the shareholders of this company: Company release, inside information...
10 hours ago
7
Apparently, quite good news? »The biomarker results obtained in the study support the further development of HER-096 as well as the planned ...
10 hours ago
by TomPettynyt
8
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